JavaScript Menu Courtesy of Milonic.com
[nucleotide sequence]     [protein sequence]     [ncbi BLAST]     [add construct]     [add ligand annotation]

HR4604D   (TRIM37)

5 targets assoicated with this target.
HR4604parentselected
HR4604Bsibling(246-418)selected
HR4604Asibling(1-132)selected
HR4604Csibling(272-413)soluble construct
HR4604Esibling(163-228)aggregation screening

database refs UniProt: O94972 (TRI37_HUMAN)   |   HUGO: TRIM37   |   NCBI gene: 4591   |   refSeq: NP_001005207.1; NP_056109.1
status X-Ray structure
structures 3LRQ (Xray)  
properties length: 81 aa   |   mass: 9.62 kD   |   pI: 6.69   |   ext: 11000   |   organism: Homo sapiens
classes Biomedical: Cancer BioNet T1 (Rutgers), Biomedical: Cancer BioNet T3 (Rutgers), Biomedical: Cancer BioNet, BioMedical, PSI-Biology
projects HCPIN    
best PDB match calculating ...
informatics Zn binding sites: CH type found (data) CHDE type found (data)
domain signatures57850 details   ZN_FING:RING-type; degenerate details   PF13923 details   3.30.40.10 details  
subsequence details   ie 100-200    
BLAST searches

Construct coverage schematic
Display constructs only from this target (HR4604D).
Display constructs associated with this target (HR4604D) and all other associated targets (HR4604, HR4604E, HR4604C, HR4604B, HR4604A).


Domain and UniProt Features
    UniProt ZN_FING:RING-type; degenerate
    Zinc finger - RING-type; degenerate domain_number-1
    Zinc finger - B box-type. {ECO:0000255|PROSITE- domain_number-1
    UniProt ZN_FING:B box-type
    PFAM PF00643
    CATH 2.60.210.10
    UniProt DOMAIN:MATH
    MATH. {ECO:0000255|PROSITE- domain_number-1
    SuperFamily 49599


NESG targets
    HR4604D
    HR4604A
    HR4604E
    HR4604B
    HR4604C

HR4604

       PDB seq homology



Constructs and Most Advanced Status
   
HR4604D-1-85-14.*

   
HR4604D-1-90-14.*

   
HR4604E-130-232-14.*

   
HR4604C-257-411-14.*

   
HR4604C-264-406-14.*

   
HR4604C-272-406-14.*



most recent record
7 years, 16 days ago --     X-Ray structure: 3lrq

2009-08-15    target: HR4604D
2009-09-23    construct: HR4604D-1-90-14.1
2009-10-12    expression [ 4, 0 ] : HR4604D-1-90-14.1-ss
2009-09-23    construct: HR4604D-1-90-14.2
2009-10-12    expression [ 4, 4 ] : HR4604D-1-90-14.2-ss
2009-10-27    expression [ 5, 1 ] : HR4604D-1-90-14.2-SeMa
2009-11-11    purification [15.1 mg]: HR4604D-1-90-14.2-SeMa-GF
2009-11-17     aggregation screening [dimer,24.59 kD,82.5%]
2009-11-13     HR4604D.001 @ Columbia; 2 ml at 6.58 mg/mL
2010-02-11     X-Ray structure: 3lrq (PDB)
2009-11-13     HR4604D.002 @ HWI; 0.45 ml at 6.58 mg/mL
2009-10-27    expression [ 5, 2 ] : HR4604D-1-90-14.2-NC5a
2009-12-09    purification [45.8 mg]: HR4604D-1-90-14.2-NC5a-Ni
    HR4604D.003 @ Rutgers; Unknown volume and concentration
2009-12-10    purification [0.1 mg]: HR4604D-1-90-14.2-NC5a-GF
2009-12-17     HR4604D.004 @ Rutgers; 0.04 ml at 0.632 mM
2010-02-08    HSQC [poor]: HR4604D.004.600MHz.20C
2009-10-27    expression [ 5, 1 ] : HR4604D-1-90-14.2-SeMb
2009-11-11    purification [15.1 mg]: HR4604D-1-90-14.2-SeMb-GF
2009-10-27    expression [ 5, 2 ] : HR4604D-1-90-14.2-NC5b
2009-12-09    purification [45.8 mg]: HR4604D-1-90-14.2-NC5b-Ni
2009-12-10    purification [0.1 mg]: HR4604D-1-90-14.2-NC5b-GF
2009-09-23    construct: HR4604D-1-85-14.3
2009-10-12    expression [ 4, 1 ] : HR4604D-1-85-14.3-ss
2009-09-23    construct: HR4604D-1-85-14.4
2009-10-12    expression [ 4, 1 ] : HR4604D-1-85-14.4-ss


Available samples:

SeMet samples
HR4604D.002 @ HWI HR4604D.001 @ Columbia


NC5 samples
HR4604D.004 @ Rutgers HR4604D.003 @ Rutgers