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HR4748B   (TCEB3)

3 targets assoicated with this target.
HR4748parentselected
HR4748Asibling(490-616)selected
HR4748Csibling(1-98)HSQC collected and crystal hits

database refs UniProt: Q14241 (ELOA1_HUMAN)   |   HUGO: TCEB3   |   NCBI gene: 6924   |   refSeq: NP_003189.2
status X-Ray structure
structures 4HFX (Xray)  
properties length: 81 aa   |   mass: 10.04 kD   |   pI: 5.03   |   ext: 18450   |   organism: Homo sapiens
classes Biomedical: Cancer BioNet T1 (Rutgers), Biomedical: Cancer BioNet T3 (Rutgers), Biomedical: Cancer BioNet, BioMedical, PSI-Biology
projects HCPIN    
best PDB match calculating ...
informatics Zn binding sites: no sites identified. CH type (data) CHDE type (data)
domain signaturesDOMAIN:F-box details   PF06881 details  
subsequence details   ie 100-200    
BLAST searches

Construct coverage schematic
Display constructs only from this target (HR4748B).
Display constructs associated with this target (HR4748B) and all other associated targets (HR4748, HR4748C, HR4748A).


Domain and UniProt Features
    CATH 1.20.930.10
    SuperFamily 47676
    UniProt DOMAIN:TFIIS N-terminal
    TFIIS N-terminal. {ECO:0000255|PROSITE- domain_number-1
    PFAM PF06881
    UniProt DOMAIN:F-box
    F-box. {ECO:0000255|PROSITE- domain_number-1


NESG targets
    HR4748C
    HR4748A
    HR4748B

HR4748

       PDB seq homology



Constructs and Most Advanced Status
   
HR4748C-1-82-14.*

   
HR4748C-1-98-14.*

   
HR4748C-1-107-15.*

   
HR4748C-1-103-15.*

   
HR4748C-1-103-14.*

   
HR4748C-1-77-14.*

   
HR4748C-1-107-14.*

   
HR4748C-17-107-15.*

   
HR4748C-17-107-14.*

   
HR4748C-22-103-15.*

   
HR4748C-22-103-14.*

   
HR4748B-535-656-14.*

   
HR4748B-543-660-14.*

   
HR4748B-546-652-14.*

   
HR4748B-546-652-15.*

   
HR4748B-549-656-14.*

   
HR4748B-550-650-14.*

   
HR4748B-550-682-14.*

   
HR4748B-557-650-14.*

   
HR4748B-571-656-14.*



most recent record
5 years, 24 days ago --     X-Ray structure: 4HFX

2009-08-15    target: HR4748B
2009-11-20    construct: HR4748B-571-656-14.1
2009-12-18    expression [ 3, 5 ] : HR4748B-571-656-14.1-ss
2009-11-20    construct: HR4748B-571-656-14.2
2009-12-18    expression [ 3, 5 ] : HR4748B-571-656-14.2-ss
2010-01-05    expression [ 3, 5 ] : HR4748B-571-656-14.2-SeMb
2010-01-05    purification [24.0 mg]: HR4748B-571-656-14.2-SeMb-GF
2010-01-20     aggregation screening [dimer,21.7 kD,98.3%]
2011-11-10     HR4748B.001 @ Columbia; 2 ml at 8.1 mg/mL
2012-10-05     X-Ray structure: 4HFX (PDB)
2011-11-10     HR4748B.002 @ HWI; 0.45 ml at 8.1 mg/mL
2010-01-05    expression [ 3, 5 ] : HR4748B-571-656-14.2-SeMa
2010-01-05    purification [24.0 mg]: HR4748B-571-656-14.2-SeMa-GF
2010-05-11    expression [ 4, 5 ] : HR4748B-571-656-14.2-NC5a
2010-06-02    purification [40.5 mg]: HR4748B-571-656-14.2-NC5a-GF
2010-06-04     HR4748B.003 @ Rutgers; 0.04 ml at 0.4 mM
2010-07-06    HSQC [poor]: HR4748B.003.600MHz.20C
2010-06-04     HR4748B.004 @ Rutgers; 2.96 ml at 0.4 mM
2010-05-11    expression [ 4, 5 ] : HR4748B-571-656-14.2-NC5b
2010-01-29    construct: HR4748B-535-656-14.3
2010-03-08    expression [ 0, 0 ] : HR4748B-535-656-14.3-ss
2010-01-29    construct: HR4748B-535-656-14.4
2010-03-08    expression [ 0, 0 ] : HR4748B-535-656-14.4-ss
2010-01-29    construct: HR4748B-543-660-14.5
2010-03-08    expression [ 0, 0 ] : HR4748B-543-660-14.5-ss
2010-01-29    construct: HR4748B-543-660-14.6
2010-03-08    expression [ 0, 0 ] : HR4748B-543-660-14.6-ss
2010-01-29    construct: HR4748B-549-656-14.7
2010-03-08    expression [ 5, 2 ] : HR4748B-549-656-14.7-ss
2010-01-29    construct: HR4748B-549-656-14.8
2010-03-08    expression [ 5, 2 ] : HR4748B-549-656-14.8-ss
2010-08-09    construct: HR4748B-546-652-14.10
2010-09-10    expression [ 3, 3 ] : HR4748B-546-652-14.10-ss
2011-06-01    expression [ 4, 2 ] : HR4748B-546-652-14.10-SeMb
2011-06-06    purification [0.0 mg]: HR4748B-546-652-14.10-SeMb-GF
2011-06-01    expression [ 4, 1 ] : HR4748B-546-652-14.10-SeMa
2011-06-06    purification [0.0 mg]: HR4748B-546-652-14.10-SeMa-GF
2011-06-01    expression [ 4, 2 ] : HR4748B-546-652-14.10-SeMc
2011-06-06    purification [0.0 mg]: HR4748B-546-652-14.10-SeMc-GF
2010-08-09    construct: HR4748B-550-650-14.11
2010-09-10    expression [ 5, 1 ] : HR4748B-550-650-14.11-ss
2010-08-09    construct: HR4748B-550-650-14.12
2010-09-10    expression [ 3, 0 ] : HR4748B-550-650-14.12-ss
2010-08-09    construct: HR4748B-550-682-14.13
2010-09-10    expression [ 5, 2 ] : HR4748B-550-682-14.13-ss
2010-08-09    construct: HR4748B-550-682-14.14
2010-09-10    expression [ 5, 2 ] : HR4748B-550-682-14.14-ss
2010-08-09    construct: HR4748B-557-650-14.15
2010-09-10    expression [ 5, 2 ] : HR4748B-557-650-14.15-ss
2010-08-09    construct: HR4748B-557-650-14.16
2010-09-10    expression [ 4, 4 ] : HR4748B-557-650-14.16-ss
2010-10-05    expression [ 4, 3 ] : HR4748B-557-650-14.16-SeMa
2010-10-11    purification [24.0 mg]: HR4748B-557-650-14.16-SeMa-GF
2010-10-18     aggregation screening [monomer,16.5 kD,59.3%|dimer,20.5 kD,24.5%]
2010-10-15     HR4748B.006 @ HWI; 0.45 ml at 8 mg/mL
2010-10-15     hR4748B.005 @ Rutgers; 2 ml at 8 mg/mL
2010-10-05    expression [ 3, 3 ] : HR4748B-557-650-14.16-SeMb
2010-10-11    purification [24.0 mg]: HR4748B-557-650-14.16-SeMb-GF
2010-11-02    expression [ 5, 5 ] : HR4748B-557-650-14.16-NC5a
2010-11-09    purification [13.5 mg]: HR4748B-557-650-14.16-NC5a-GF
2010-11-24     HR4748B.007 @ Rutgers; 0.05 ml at 1.28 mM
2010-12-13    HSQC [poor]: HR4748B.007.600MHz.20C
2010-11-24     HR4748B.008 @ Rutgers; 0.5 ml at 1.28 mM
2010-11-02    expression [ 5, 5 ] : HR4748B-557-650-14.16-NC5b
2010-08-09    construct: HR4748B-546-652-15.17
2010-09-10    expression [ 5, 0 ] : HR4748B-546-652-15.17-ss


Available samples:

SeMet samples
HR4748B.002 @ HWI hR4748B.005 @ Rutgers HR4748B.006 @ HWI HR4748B.001 @ Columbia


NC5 samples
HR4748B.004 @ Rutgers
HR4748B.007 @ Rutgers HR4748B.003 @ Rutgers HR4748B.008 @ Rutgers