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HR5601B   (ALKBH8)

3 targets assoicated with this target.
HR5601Csibling(126-663)selected
HR5601parentcloned
HR5601Asibling(352-663)cloned

database refs UniProt: Q96BT7 (ALKB8_HUMAN)   |   HUGO: ALKBH8   |   NCBI gene: 91801   |   refSeq: NP_620130.2
status X-Ray structure
structures 3THT (Xray)   3THP (Xray)  
properties length: 331 aa   |   mass: 37.51 kD   |   pI: 6.61   |   ext: 38390   |   organism: Homo sapiens
classes PSI-2, Community Outreach, MEGA, NESG-BIG-STRUCTURE, PSI-Biology, Epigenetics: List B
projects EPI list B     PSI:Biology Partner - EpiG    
best PDB match calculating ...
informatics Zn binding sites: no sites identified. CH type (data) CHDE type (data)
domain signatures51197 details   2.60.120.590 details   BIG_205 details   METAL:Iron; catalytic (By similarity) details   DOMAIN:Fe2OG dioxygenase details   PF13532 details   DOMAIN:RRM details  
subsequence details   ie 100-200    
BLAST searches

Construct coverage schematic
Display constructs only from this target (HR5601B).
Display constructs associated with this target (HR5601B) and all other associated targets (HR5601, HR5601A, HR5601C).


Domain and UniProt Features
    UniProt DOMAIN:RRM
    RRM domain_number-1
    SuperFamily 51197
    PFAM PF13532
    BIG BIG_205
    Fe2OG dioxygenase. {ECO:0000255|PROSITE- domain_number-1
    UniProt DOMAIN:Fe2OG dioxygenase
    Iron; catalytic. {ECO:0000255|PROSITE- domain_number-1
    Iron; catalytic. {ECO:0000255|PROSITE- domain_number-2
    Zinc; via pros nitrogen domain_number-1
    UniProt METAL:Iron; catalytic (By similarity)
    Iron; catalytic. {ECO:0000255|PROSITE- domain_number-3
    Binding - Alpha-ketoglutarate domain_number-1
    Binding - Alpha-ketoglutarate domain_number-2
    Zinc. {ECO:0000269|PubMed:22065580} domain_number-1
    Zinc. {ECO:0000269|PubMed:22065580} domain_number-2
    Zinc. {ECO:0000269|PubMed:22065580} domain_number-3
    CATH 3.40.50.150
    CATH 3.40.50.150


NESG targets
    HR5601B
    HR5601C
    HR5601A

HR5601

       PDB seq homology



Constructs and Most Advanced Status
   
HR5601B-28-352-21.*

   
HR5601B-28-350-21.*

   
HR5601B-21.*



most recent record
6 years, 6 days ago --     X-Ray structure: 3tht; X-Ray structure: 3thp

2010-07-16    target: HR5601B
2010-07-01    construct: HR5601B-21.1
0002-07-01    expression [ -1, -1 ] : HR5601B-21.1-SeMa
2010-07-16    purification [0.0 mg]: HR5601B-21.1-SeMa-GF
2010-07-17     HR5601B.001 @ Rutgers; 0.46 ml at 10.2 mg/mL
2011-08-19     X-Ray structure: 3tht (PDB)
2011-08-19     X-Ray structure: 3thp (PDB)
2010-08-05    construct: HR5601B-28-350-21.2
2010-08-10    expression [ -1, -1 ] : HR5601B-28-350-21.1-Lba
2010-08-10    purification [2.6 mg]: HR5601B-28-350-21.1-Lba-GF
2010-08-10     HR5601B.002 @ Rutgers; 0.46 ml at 5.6 mg/mL
2010-08-05    construct: HR5601B-28-352-21.3
2010-08-10    expression [ -1, -1 ] : HR5601B-28-352-21.3-Lba
2010-08-10    purification [2.6 mg]: HR5601B-28-352-21.3-Lba-GF
2010-08-10     HR5601B.003 @ Rutgers; 0.46 ml at 5.6 mg/mL


Available samples:

LB samples
HR5601B.003 @ Rutgers HR5601B.002 @ Rutgers


SeMet samples
HR5601B.001 @ Rutgers