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HR6723   (HDDC2)

1 targets assoicated with this target.
HR6723Achild(15-170)HSQC collected

database refs UniProt: Q7Z4H3 (HDDC2_HUMAN)   |   HUGO: HDDC2   |   NCBI gene: 51020   |   refSeq: NP_057147.2
status X-Ray structure
structures 4DMB (Xray)   4L1J (Xray)   4L7W (Xray)   4L7E (Xray)  
properties length: 204 aa   |   mass: 23.39 kD   |   pI: 5.33   |   ext: 19940   |   organism: Homo sapiens
classes MPP: Biomedical, PSI-Biology, MPP: Structural Coverage
projects MPP structural coverage     MPP biomedical targets     MPP structural coverage targets     PSI:Biology Partner - MPP    
best PDB match calculating ...
informatics Zn binding sites: no sites identified. CH type (data) CHDE type (data)
domain signatures109604 details   PF13023 details   DOMAIN:HD details   1.10.3210.10 details  
subsequence details   ie 100-200    
BLAST searches

Construct coverage schematic
Display constructs only from this target (HR6723).
Display constructs associated with this target (HR6723) and all other associated targets (HR6723A).


Domain and UniProt Features
    SuperFamily 109604
    CATH 1.10.3210.10
    PFAM PF13023
    HD. {ECO:0000255|PROSITE- domain_number-1
    UniProt DOMAIN:HD


NESG targets
    HR6723A

HR6723

       PDB seq homology



Constructs and Most Advanced Status
   
MPP-GO.123128-1-204

   
MPP-GO.111587-1-204

   
HR6723-D78A-Q131R-15.*

   
HR6723-D143A-Q131R-15.*

   
HR6723-H49A-Q131R-15.*

   
HR6723-H77A-Q131R-15.*

   
HR6723A-7-181-15.*

   
HR6723-7-204-15.*

   
HR6723A-11-176-15.*

   
HR6723-11-204-15.*

   
HR6723-29-204-15.*

   
HR6723A-29-176-15.*



most recent record
4 years, 25 days ago --     X-Ray structure: 4l1j

2010-09-17    target: HR6723
2011-02-10    construct: HR6723-29-204-15.3
2011-02-21    expression [ 3, 5 ] : HR6723-29-204-15.3-ss
2011-05-18    expression [ 3, 5 ] : HR6723-29-204-15.3-SeMb
2011-05-25    purification [12.8 mg]: HR6723-29-204-15.3-SeMb-GF
2011-06-01     aggregation screening [dimer,49.34 kD,78.4%]
2011-05-31     hr6723.005 @ Rutgers; 0.723 ml at 7.89 mg/mL
2011-05-31     HR6723.006 @ HWI; 0.45 ml at 7.89 mg/mL
2013-05-14     hr6723.023 @ MPP; 1 ml at 1 mg/mL
2011-05-18    expression [ 3, 5 ] : HR6723-29-204-15.3-SeMa
2011-05-25    purification [12.8 mg]: HR6723-29-204-15.3-SeMa-GF
2011-07-26    expression [ 4, 5 ] : HR6723-29-204-15.3-NC5b
2011-09-09    purification [74.4 mg]: HR6723-29-204-15.3-NC5b-Ni
2011-09-11    purification [26.2 mg]: HR6723-29-204-15.3-NC5b-GF
2011-07-26    expression [ 4, 4 ] : HR6723-29-204-15.3-NC5a
2011-09-09    purification [74.4 mg]: HR6723-29-204-15.3-NC5a-Ni
2011-09-11    purification [26.2 mg]: HR6723-29-204-15.3-NC5a-GF
2011-09-27     HR6723.007 @ Rutgers; 0.04 ml at 0.704463 mM
2011-10-26    HSQC [poor]: HR6723.007.600MHz.20C
2013-05-14     hr6723.022 @ MPP; 1 ml at 1 mg/mL
2011-02-10    construct: HR6723-29-204-15.4
2011-02-21    expression [ 3, 4 ] : HR6723-29-204-15.4-ss
2011-02-10    construct: HR6723-7-204-15.6
2011-02-21    expression [ 3, 4 ] : HR6723-7-204-15.6-ss
2011-02-11    construct: HR6723-11-204-15.9
2011-02-21    expression [ 4, 5 ] : HR6723-11-204-15.9-ss
2011-02-11    construct: HR6723-11-204-15.10
2011-02-21    expression [ 4, 5 ] : HR6723-11-204-15.10-ss
2011-04-06    expression [ 3, 5 ] : HR6723-11-204-15.10-NC5a
2011-04-20    purification [5.8 mg]: HR6723-11-204-15.10-NC5a-Ni
2011-04-23    purification [7.0 mg]: HR6723-11-204-15.10-NC5a-GF
2011-04-27     HR6723.003 @ Rutgers; 0.04 ml at 0 mM
2011-04-06    expression [ 3, 5 ] : HR6723-11-204-15.10-SeMa
2011-04-18    purification [27.0 mg]: HR6723-11-204-15.10-SeMa-GF
2011-04-26     aggregation screening [trimer,61.41 kD,74.7%|heptamer,138.4 kD,19.4%]
2011-04-22     hr6723.001 @ Columbia; 1.9 ml at 8.5 mg/mL
2012-02-07     X-Ray structure: 4dmb (PDB)
2011-04-22     HR6723.002 @ HWI; 0.45 ml at 8.5 mg/mL
2013-05-15    expression [ 4, 5 ] : HR6723-11-204-15.10-LBa
2013-05-20    purification [89.4 mg]: HR6723-11-204-15.10-[LBa,LBb]-Ni
2013-05-20    purification [89.0 mg]: HR6723-11-204-15.10-[LBa,LBb]-GF
2013-05-22     HR6723.008 @ Rutgers; 0.04 ml at 0.61 mM
2013-05-22     HR6723.027 @ Rutgers; 3.46 ml at 0.61 mM
2013-05-15    expression [ 5, 5 ] : HR6723-11-204-15.10-LBb
2011-02-11    construct: HR6723-7-204-15.14
2011-02-21    expression [ 3, 4 ] : HR6723-7-204-15.14-ss
2012-06-25    construct: HR6723-H49A-Q131R-15.15
2012-09-26    expression [ 4, 5 ] : HR6723-H49A-Q131R-15.15-SeM-R1
2012-10-02    purification [75.0 mg]: HR6723-H49A-Q131R-15.15-SeM-R1-Ni
2012-10-03    purification [70.4 mg]: HR6723-H49A-Q131R-15.15-SeM-R1-GF
2012-10-10     aggregation screening [dimer,42.06 kD,61.3%|dimer,39.22 kD,32.9%]
2012-10-09     HR6723.004 @ HWI; 0.45 ml at 10.06 mg/mL
2012-10-09     HR6723.009 @ Columbia; 2 ml at 10.06 mg/mL
2012-10-09     HR6723.010 @ Rutgers; 2.901 ml at 10.06 mg/mL
2013-05-14     hr6723.024 @ MPP; 1 ml at 1 mg/mL
2012-06-25    construct: HR6723-D143A-Q131R-15.18
2012-09-26    expression [ 5, 5 ] : HR6723-D143A-Q131R-15.18-SeM-R1
2012-10-02    purification [108.8 mg]: HR6723-D143A-Q131R-15.18-SeM-R1-Ni
2012-10-03    purification [111.6 mg]: HR6723-D143A-Q131R-15.18-SeM-R1-GF
2012-10-10     aggregation screening [dimer,61.27 kD,68.3%|heptamer,162.6 kD,24.65%]
2012-10-09     HR6723.011 @ HWI; 0.45 ml at 10.03 mg/mL
2012-10-09     HR6723.012 @ Columbia; 2 ml at 10.03 mg/mL
2013-07-01     X-Ray structure: 4l1j (PDB)
2012-10-09     HR6723.013 @ Rutgers; 1.5 ml at 10.03 mg/mL
2012-06-25    construct: HR6723-D78A-Q131R-15.17
2012-09-26    expression [ 5, 5 ] : HR6723-D78A-Q131R-15.17-SeM-R1
2012-10-02    purification [84.6 mg]: HR6723-D78A-Q131R-15.17-SeM-R1-Ni
2012-10-03    purification [86.4 mg]: HR6723-D78A-Q131R-15.17-SeM-R1-GF
2012-10-10     aggregation screening [dimer,44.42 kD,92.5%]
2012-10-09     HR6723.014 @ HWI; 0.45 ml at 9.9 mg/mL
2012-10-09     HR6723.015 @ Columbia; 2 ml at 9.9 mg/mL
2013-06-13     X-Ray structure: 4l7e (PDB)
2012-10-09     HR6723.016 @ Rutgers; 0.2 ml at 9.9 mg/mL
2013-05-14     hr6723.025 @ MPP; 1 ml at 1 mg/mL
2012-06-25    construct: HR6723-H77A-Q131R-15.16
2012-09-26    expression [ 5, 5 ] : HR6723-H77A-Q131R-15.16-SeM-R1
2012-10-02    purification [81.6 mg]: HR6723-H77A-Q131R-15.16-SeM-R1-Ni
2012-10-03    purification [97.2 mg]: HR6723-H77A-Q131R-15.16-SeM-R1-GF
2012-10-10     aggregation screening [dimer,43.66 kD,73.0%|dimer,40.35 kD,20.3%]
2012-10-09     HR6723.017 @ HWI; 0.45 ml at 10.19 mg/mL
2012-10-09     HR6723.018 @ Columbia; 2 ml at 10.19 mg/mL
2013-06-14     X-Ray structure: 4l7w (PDB)
2012-10-09     HR6723.019 @ Rutgers; 5.902 ml at 10.19 mg/mL
2013-05-14     hr6723.026 @ MPP; 1 ml at 1 mg/mL
2013-05-14     HR6723.020 @ MPP; 0.002 ml at 0.05 mg/mL
2013-05-14     HR6723.021 @ MPP; 0.002 ml at 0.05 mg/mL


Available samples:

SeMet samples
HR6723.017 @ HWI HR6723.016 @ Rutgers HR6723.004 @ HWI HR6723.019 @ Rutgers HR6723.011 @ HWI
HR6723.002 @ HWI hr6723.025 @ MPP hr6723.026 @ MPP hr6723.023 @ MPP HR6723.015 @ Columbia
HR6723.010 @ Rutgers hr6723.024 @ MPP HR6723.018 @ Columbia HR6723.009 @ Columbia HR6723.013 @ Rutgers
HR6723.012 @ Columbia hr6723.005 @ Rutgers HR6723.014 @ HWI HR6723.006 @ HWI hr6723.001 @ Columbia


Labeling not defined samples
HR6723.027 @ Rutgers HR6723.008 @ Rutgers


NC5 samples
hr6723.022 @ MPP HR6723.007 @ Rutgers HR6723.003 @ Rutgers


E-mail communications associated with this target:

  2012-10-10
  2012-10-11
  2012-10-16
  2013-05-15
  2013-05-15
  2013-05-15
  2013-05-15