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HR7907F   (ZHX1)

6 targets assoicated with this target.
HR7907parentselected
HR7907Asibling(60-153)soluble construct with good ES score
HR7907Bsibling(565-641)soluble construct with excellent ES score
HR7907Csibling(298-357)purified
HR7907Esibling(658-733)purified
HR7907Dsibling(768-843)HSQC collected

database refs UniProt: Q9UKY1 (ZHX1_HUMAN)   |   HUGO: ZHX1   |   NCBI gene: 11244   |   refSeq: NP_001017926.1; NP_009153.3
status NMR structure
structures 2LY9 (NMR)  
properties length: 76 aa   |   mass: 8.83 kD   |   pI: 9.73   |   ext: 8480   |   organism: Homo sapiens
classes Biomedical: Cancer BioNet, Biomedical: Transcription Factor, PSI-Biology
projects HCPIN     Transcription Factor    
best PDB match calculating ...
informatics Dismeta report   |   Zn binding sites: no sites identified. CH type (data) CHDE type (data)
domain signaturesDNA_BIND:Homeobox 2 details   1.10.10.60 details   46689 details   PF00046 details  
subsequence details   ie 100-200    
BLAST searches

Construct coverage schematic
Display constructs only from this target (HR7907F).
Display constructs associated with this target (HR7907F) and all other associated targets (HR7907, HR7907C, HR7907B, HR7907E, HR7907A, HR7907D).


Domain and UniProt Features
    Zinc finger - C2H2-type 1. {ECO:0000255|PROSITE- domain_number-1
    UniProt ZN_FING:C2H2-type 1
    SuperFamily 57667
    Zinc finger - C2H2-type 2. {ECO:0000255|PROSITE- domain_number-1
    UniProt ZN_FING:C2H2-type 2
    Homeobox 1. {ECO:0000255|PROSITE- domain_number-1
    CATH 1.10.10.60
    UniProt DNA_BIND:Homeobox 1
    SuperFamily 46689
    CATH 1.10.10.60
    UniProt DNA_BIND:Homeobox 2
    Homeobox 2. {ECO:0000255|PROSITE- domain_number-1
    PFAM PF00046
    SuperFamily 46689
    CATH 1.10.10.60
    Homeobox 3. {ECO:0000255|PROSITE- domain_number-1
    UniProt DNA_BIND:Homeobox 3
    PFAM PF00046
    CATH 1.10.10.60
    SuperFamily 46689
    UniProt DNA_BIND:Homeobox 4
    Homeobox 4. {ECO:0000255|PROSITE- domain_number-1
    PFAM PF00046
    SuperFamily 46689
    CATH 1.10.10.60
    PFAM PF11569
    Homeobox 5. {ECO:0000255|PROSITE- domain_number-1
    UniProt DNA_BIND:Homeobox 5


NESG targets
    HR7907A
    HR7907C
    HR7907F
    HR7907B
    HR7907E
    HR7907D

HR7907

       PDB seq homology



Constructs and Most Advanced Status
   
HR7907A-60-153-TEV.*

   
HR7907C-295-358-Av6HT.*

   
HR7907F-462-532-Av6HT.*

   
HR7907F-468-513-Av6HT.*

   
HR7907F-468-532-Av6HT.*

   
HR7907B-565-641-TEV.*

   
HR7907E-658-720-Av6HT.*

   
HR7907E-658-728-Av6HT.*

   
HR7907D-768-820-Av6HT.*

   
HR7907D-768-830-Av6HT.*



most recent record
4 years, 15 days ago --     aggregation screening [monomer,14.31 kD,95.0%]

2011-08-17    target: HR7907F
2011-10-11    construct: HR7907F-468-532-Av6HT.6
2011-10-31    expression [ 3, 2, not tested ]: HR7907F-468-532-Av6HT.6-ss
2011-10-11    construct: HR7907F-468-532-Av6HT.5
2011-10-31    expression [ 3, 5, not tested ]: HR7907F-468-532-Av6HT.5-ss
2011-10-11    construct: HR7907F-468-513-Av6HT.4
2011-10-31    expression [ 5, 0, not tested ]: HR7907F-468-513-Av6HT.4-ss
2011-10-11    construct: HR7907F-468-513-Av6HT.3
2011-10-31    expression [ 5, 0, not tested ]: HR7907F-468-513-Av6HT.3-ss
2011-10-11    construct: HR7907F-462-532-Av6HT.2
2011-10-31    expression [ 4, 4, not tested ]: HR7907F-462-532-Av6HT.2-ss
2011-12-07    expression [ 4, 4, not tested ]: HR7907F-462-532-Av6HT.2-NC5b
2011-12-22    purification [7.5 mg]: HR7907F-462-532-Av6HT.2-NC5b-Ni
2011-12-23    purification [3.2 mg]: HR7907F-462-532-Av6HT.2-NC5b-GF
2011-12-07    expression [ 4, 4, not tested ]: HR7907F-462-532-Av6HT.2-NC5c
2011-12-22    purification [7.5 mg]: HR7907F-462-532-Av6HT.2-NC5c-Ni
2011-12-23    purification [3.2 mg]: HR7907F-462-532-Av6HT.2-NC5c-GF
2011-12-07    expression [ 4, 3, not tested ]: HR7907F-462-532-Av6HT.2-NC5a
2011-12-22    purification [7.5 mg]: HR7907F-462-532-Av6HT.2-NC5a-Ni
2011-12-23    purification [3.2 mg]: HR7907F-462-532-Av6HT.2-NC5a-GF
2013-09-10     aggregation screening [monomer,14.31 kD,95.0%]
2012-01-02     HR7907F.001 @ Rutgers; 0.04 ml at 0.528 mM
2012-01-24    HSQC [good]: HR7907F.001.600MHz.20C
2012-01-04     HR7907F.002 @ Rutgers; 0.1 ml at 0.52799 mM
2012-01-04     hr7907f.003 @ Rutgers; 1 ml at 1 mg/mL
2012-02-01    expression [ 5, 5, not tested ]: HR7907F-462-532-AV6HT.2-NCa
2012-02-07    purification [13.3 mg]: HR7907F-462-532-AV6HT.2-NCa-Ni
2012-02-07    purification [10.1 mg]: HR7907F-462-532-AV6HT.2-NCa-GF
2012-05-03     HR7907F.005 @ Buffalo; 0.3 ml at 0.417453 mM
2012-09-17     NMR structure: 2ly9 (PDB)
2012-02-07    purification [11.7 mg]: HR7907F-462-532-Av6HT.2-NCa-TV
2012-02-01    expression [ 5, 5, not tested ]: HR7907F-462-532-AV6HT.2-NC5d
2012-02-07    purification [15.1 mg]: HR7907F-462-532-AV6HT.2-NC5d-Ni
2012-02-07    purification [2.0 mg]: HR7907F-462-532-AV6HT.2-NC5d-GF
2012-05-03     HR7907F.006 @ Buffalo; 0.5 ml at 0.339505 mM
2012-02-07    purification [13.2 mg]: HR7907F-462-532-Av6HT.2-NC5d-TV
2011-10-11    construct: HR7907F-462-532-Av6HT.1
2011-10-31    expression [ 4, 4, not tested ]: HR7907F-462-532-Av6HT.1-ss
2012-06-15    expression [ 5, 1, not tested ]: HR7907F-462-532-Av6HT.1-ZYMa
2012-06-25    purification [0.5 mg]: HR7907F-462-532-Av6HT.1-ZYMa-Ni
2012-07-03     HR7907f.007 @ RAN - Chicago; 1.95 ml at 0.3 mg/mL
2012-06-15    expression [ 5, 1, not tested ]: HR7907F-462-532-Av6HT.1-ZYMb
2012-06-25    purification [0.5 mg]: HR7907F-462-532-Av6HT.1-ZYMb-Ni


Available samples:

Labeling not defined samples
HR7907f.007 @ RAN - Chicago


NC samples
HR7907F.005 @ Buffalo


NC5 samples
HR7907F.006 @ Buffalo HR7907F.001 @ Rutgers HR7907F.002 @ Rutgers
hr7907f.003 @


E-mail communications associated with this target:

  2012-08-14
  2013-05-17
  2013-05-17