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HR9134A   (INPPL1)

1 targets assoicated with this target.
HR9134parentselected

database refs UniProt: O15357 (SHIP2_HUMAN)   |   HUGO: INPPL1   |   NCBI gene: 3636
status NMR structure
structures 2MK2 (NMR)  
properties length: 120 aa   |   mass: 12.94 kD   |   pI: 4.92   |   ext: 11460   |   organism: Homo sapiens
classes Biomedical: Cancer BioNet, PSI-Biology
projects HCPIN    
best PDB match calculating ...
informatics Zn binding sites: no sites identified. CH type (data) CHDE type (data)
domain signatures3.30.505.10 details   PF00017 details   55550 details   DOMAIN:SH2 details  
subsequence details   ie 100-200    
BLAST searches

Construct coverage schematic
Display constructs only from this target (HR9134A).
Display constructs associated with this target (HR9134A) and all other associated targets (HR9134).


Domain and UniProt Features
    UniProt DOMAIN:SH2
    SH2. {ECO:0000255|PROSITE- domain_number-1
    SuperFamily 56219
    CATH 3.60.10.10
    PFAM PF03372
    UniProt MOTIF:SH3-binding
    SH3-binding domain_number-1
    NPXY motif domain_number-1
    UniProt MOTIF:NPXY motif
    SAM. {ECO:0000255|PROSITE- domain_number-1
    UniProt DOMAIN:SAM


NESG targets
    HR9134A

HR9134

       PDB seq homology



Constructs and Most Advanced Status
   
HR9134A-20-117-15.*



most recent record
3 years, 1 day ago --     NMR structure: 2mk2

2012-01-12    target: HR9134A
2012-04-10    construct: HR9134A-20-117-15.8
2012-06-29    expression [ 4, 3 ] : HR9134A-20-117-15.8-ss
2012-04-10    construct: HR9134A-20-117-15.4
2012-06-29    expression [ 4, 4 ] : HR9134A-20-117-15.4-ss
2013-02-27    expression [ 5, 2 ] : HR9134A-20-117-15.4-SeMa
2013-02-27    expression [ 5, 2 ] : HR9134A-20-117-15.4-NC5a
2013-03-18    purification [68.7 mg]: HR9134A-20-117-15.4-NC5a-GF
2013-05-20     aggregation screening [monomer,13.16 kD,66.3%|dimer,22.6 kD,24.3%]
2013-03-21     HR9134A.001 @ Rutgers; 0.04 ml at 1.05 mM
2013-04-12    HSQC [good]: HR9134A.001.600MHz.20C
2013-03-21     HR9134A.002 @ Rutgers; 3.46 ml at 1.1 mM
2013-06-05     HR9134A.006 @ UGA; 1 ml at 1.05 mM
2013-06-05     HR9134A.005 @ Miami; 0.5 ml at 1.05 mM
2013-05-07    expression [ 5, 5 ] : HR9134A-20-117-15.4-NC-R1
2013-05-13    purification [42.1 mg]: HR9134A-20-117-15.4-NC-R1-Ni
2013-05-13    purification [64.8 mg]: HR9134A-20-117-15.4-NC-R1-GF
2013-05-15     HR9134A.003 @ Miami; 0.3 ml at 1.15 mM
2013-05-15     HR9134A.004 @ Rutgers; 3.4 ml at 0.58 mM
2013-06-13     HR9134A.007 @ Miami; 0.3 ml at 0.58 mM
2013-09-19     HR9134A.010 @ Miami; 1 ml at 0.58 mM
2014-01-23     NMR structure: 2mk2 (PDB)
2013-05-07    expression [ 5, 2 ] : HR9134A-20-117-15.4-NC5-R1
2013-07-18    purification [59.3 mg]: HR9134A-20-117-15.4-NC5-R1-GF
2013-07-23     HR9134A.009 @ Rutgers; 5 ml at 1.042 mM
2013-07-18    purification [48.2 mg]: HR9134A-20-117-15.4-NC5-R1-Ni
2013-05-15    expression [ 5, 2 ] : HR9134A-20-117-15.4-NCa
2013-07-18    purification [40.1 mg]: HR9134A-20-117-15.4-NCa-GF
2013-07-23     HR9134A.008 @ Rutgers; 3 ml at 1.076 mM
2013-07-18    purification [44.0 mg]: HR9134A-20-117-15.4-NCa-Ni


Available samples:

NC samples
HR9134A.010 @ Miami HR9134A.004 @ Rutgers HR9134A.008 @ Rutgers HR9134A.007 @ Miami HR9134A.003 @ Miami


NC5 samples
HR9134A.009 @ Rutgers HR9134A.002 @ Rutgers HR9134A.006 @ UGA HR9134A.005 @ Miami HR9134A.001 @ Rutgers


E-mail communications associated with this target:

  2013-06-06
  2013-06-06
  2013-06-07
  2013-06-07
  2013-06-10
  2013-06-10
  2013-06-17
  2013-06-17
  2013-06-19
  2013-06-19
  2013-08-16
  2013-08-16
  2013-09-20
  2013-09-23